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Human papillomavirus (HPV) oropharyngeal squamous cell carcinoma (OPSCC) is a distinct entity with RTOG 0129 reporting long-term overall survival (OS) of 71% for stage III/IV HPV disease compared with 30% for HPV-negative tumors after concurrent chemoradiotherapy (CRT) .
They addressed such unmet need in terms of detection of NTRK fusions together with a group of experts on behalf of the ESMO Translational Research and Precision Medicine Working Group.
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Mozart's great comic opera of intrigue, misunderstanding and forgiveness returns with Christian Gerhaher and Simon Keenlyside as the clever Figaro and his aristocratic master.
Impressive anticancer activity has been shown by kinase inhibitors, which target aberrant signalling in the 50% of melanomas with BRAF mutations, and antibodies that bind to the immune checkpoints cytotoxic T-lymphocyte antigen 4 (CTLA-4) or programmed death 1 (PD1) [1–3].